Results 31 to 40 of about 8,913 (312)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Cylindrical vector beam multiplexer/demultiplexer using off-axis polarization control

Light: Science & Applications, 2021
The emergence of cylindrical vector beam (CVB) multiplexing has opened new avenues for high-capacity optical communication. Although several configurations have been developed to couple/separate CVBs, the CVB multiplexer/demultiplexer remains elusive due
Shuqing Chen, Zhiqiang Xie, Huapeng Ye, Xinrou Wang, Zhenghao Guo, Yanliang He, Ying Li, Xiaocong Yuan, Dianyuan Fan   +8 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Silicon-Based-Chip Multiplexing Technologies and Devices

Dianxin kexue, 2015
As the demands of the data communications increase quickly for the applications of cloud-computing as well as data centers，optical interconnects have been very attractive because of the unique advantages on the aspects of low power consumption，high speed
Daoxin Dai, Jian Wang, Sitao Chen
doaj   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Сompensator of polarization mode dispersion based on spiral-wound single-mode fiber [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2013
A polarization mode dispersion (PMD) compensator for single-mode optical fiber has been designed. Its operation principle is based on the use of artificial difference of phase velocities of the basic ordinary and extraordinary waves in spiral-wound fiber,
Bagachuk D. G.
doaj   +2 more sources

Ultra-Broadband Polymer 1 × 2 Thermo-Optic Mode Switch

IEEE Photonics Journal, 2021
Optical mode switch is a key device for reconfigurable mode-division-multiplexing (MDM) technique. Here, an ultra-broadband 1×2 mode switch based on cascaded Mach-Zehnder interferometer and asymmetric Y-branch is proposed.
Yang Gao, Yan Xu, Songyue Liu, Xiaojian Fan, Xibin Wang, Xiaoqiang Sun, Daming Zhang   +6 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

95.16-Gb/s Mode-Division-Multiplexing Signal Transmission in Free-Space Enabled by Effective-Conversion of Vector Beams

IEEE Photonics Journal, 2017
We introduce a high-efficient vector modes (VMs) conversion scheme by using Q-plate (QP) and half-waveplate based on higher-order Poincaré sphere model.
Jianbo Zhang, Fan Li, Jianping Li, Zhaohui Li   +3 more
doaj   +1 more source