Results 131 to 140 of about 5,233,866 (349)

I SHAKLLANTIRISHNING METODIK MODELI

, 2023
Annotasiya. Maqolada talabalarning kreativ faoliyatini rivojlantirishda tasavvurni rivojlantirish usullarining ahamiyati bayon qilingan.
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Mode I Fatigue of Fibre Reinforced Polymeric Composites: A Review. [PDF]

Polymers (Basel), 2022
Gao X, Umair M, Nawab Y, Latif Z, Ahmad S, Siddique A, Yang H.   +6 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Turbulence link to L-mode, I-mode, and H-mode confinement in the DIII-D tokamak

Nuclear Fusion
Understanding the physics of low-confinement (L-), improved-confinement (I-), and high-confinement (H-) modes is critical for fusion reactors. The finding herein reports observations of two types of turbulence coexisting near the L-mode edge, one ...
J. Chen, D.L. Brower, J. McClenaghan, Z. Yan, A.E. Hubbard, R. Groebner   +5 more
doaj   +1 more source

Numerical study and experimental validation of the size effect of smooth and mode I cracked semi-circular bend specimens. [PDF]

Sci Rep, 2023
Mousa S, Mutnbak M, Saba AM, Abd-Elhady AA, Sallam HEM.   +4 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sunspot Seismology: The Interaction of Solar p-Modes with a Sunspot [PDF]

, 1993
John H. Thomas
openalex   +1 more source

A Fatigue Model to Predict Interlaminar Damage of FRP Composite Laminates Subjected to Mode I Load. [PDF]

Polymers (Basel), 2023
Khan SA, Rahimian Koloor SS, King Jye W, Siebert G, Tamin MN.   +4 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source