Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Mode 1 delamination growth in adhesively bonded joints under static and fatigue loads [PDF]
The objective of this investigation was to characterize the pure mode 1 delamination growth in metal to metal adhesively bonded joints under static and fatigue loading conditions, using FM 73 adhesive. Double cantilever beam specimens (DCB) were used for
Biswas, S. C., Jeelani, S.
core +1 more source
Fracture analysis-based mode-I stress intensity factors of crack under fracture grouting in elastic-plastic soils. [PDF]
Sci Rep, 2023 Li L, Deng Y.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
High Strain Rate Response of Adhesively Bonded Fiber-Reinforced Composite Joints A Computational Study to Guide Experimental Design [PDF]
Adhesively bonded carbon fiber-reinforced epoxy composite laminates are widely used in aerospace applications. During a high energy impact event, these laminates are often subjected to high strain rate loading.
Justusson, Brian +5 more
core +1 more source
Delamination of Novel Carbon Fibre-Based Non-Crimp Fabric-Reinforced Thermoplastic Composites in Mode I: Experimental and Fractographic Analysis. [PDF]
Polymers (Basel), 2023 Mohsin MAA, Iannucci L, Greenhalgh ES.
europepmc +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Numerical and Experimental Analysis of the Mode I Interlaminar Fracture Toughness in Multidirectional 3D-Printed Thermoplastic Composites Reinforced with Continuous Carbon Fiber. [PDF]
Polymers (Basel), 2023 Santos JD +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source