Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Mode I Fracture Toughness of Rock - Intrinsic Property or Pressure-Dependent?
, 2016 Ferdinand Stoeckhert +4 more
openalex +1 more source
Mode of Operation of Ampullae of Lorenzini of the Skate, Raja [PDF]
, 1972 S. Obara, Michael V. L. Bennett
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Effects of Aging on Mode I Fatigue Crack Growth Characterization of Double Cantilever Beam Specimens with Thick Adhesive Bondline for Marine Applications. [PDF]
Materials (Basel)Iyer Kumar R, De Waele W.
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The conformation of ribonucleic acids in Escherichia coli ribosomes. Inferences from the mode of action of ribonuclease II [PDF]
, 1967 M. Artman, Nitza Silman, Hanna Engelberg
openalex +1 more source
Effects of specimen geometry and size on mode I and mixed mode fracture behavior of high strength fiber reinforced concrete. [PDF]
Sci RepMutnbak M +5 more
europepmc +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Criterion for Combined Mode I-II of Brittle Fracture.
, 1999 Hideo Awaji +3 more
openalex +2 more sources
Environmental Effects of Moisture and Elevated Temperatures on the Mode I and Mode II Interlaminar Fracture Toughness of a Toughened Epoxy Carbon Fibre Reinforced Polymer. [PDF]
Polymers (Basel)Williams A, Hamerton I, Allegri G.
europepmc +1 more source