By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Dynamic properties of mode I and mode II fractures of shale under impact loading
Controllable shock wave fracturing is an innovative engineering technique used for shale reservoir fracturing and reformation. Understanding the anisotropic fracture mechanism of shale under impact loading is vital for optimizing shock wave fracturing ...
Zelin Yan +3 more
doaj +1 more source
Spinor Field with Polynomial Nonlinearity in LRS Bianchi type-I spacetime
Within the scope of Bianchi type-I cosmological model the role of spinor field on the evolution of the Universe is investigated. In doing so we have considered a polynomial type of nonlinearity.
Saha, Bijan
core +1 more source
A thermodynamically consistent derivation of a frictional-damage cohesive-zone model with different mode i and mode II fracture energies [PDF]
The present paper deals with the derivation of an interface model characterized by macroscopic fracture energies which are different in modes I and II, the macroscopic fracture energy being the total energy dissipated per unit of fracture area.
Alfano, G, Sacco, E, Serpieri, R
core +1 more source
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Experimental identification of I-mode characteristics at the edge of FIRE mode in KSTAR
The edge region of the recently discovered fast ion-regulated enhancement mode (FIRE mode) (Han and Park et al 2022 Nature 609 269–275), which primarily operates in the unfavorable ion $\nabla B$ drift configuration, is investigated in detail for the ...
Chweeho Heo +10 more
doaj +1 more source
Cosmic Shear E/B-mode Estimation with Binned Correlation Function Data
In this work I study the problem of E/B-mode separation with binned cosmic shear two-point correlation function data. Motivated by previous work on E/B-mode separation with shear two-point correlation functions and the practical considerations of data ...
Antonik +122 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Crack front instabilities under mixed mode loading in three dimensions
The evolution of a crack front under mixed mode loading (I+III) is studied using a phase field model in 3 dimensions with no stress boundary conditions. As previously observed experimentally in gels, there is a relaxation toward a geometry where $K_{III}=
Henry, Hervé
core +2 more sources
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source

