Results 131 to 140 of about 548,685 (259)

Raman and SERS Spectra of Human Myelin Basic Protein in Cerebrospinal Fluid. [PDF]

Nanomaterials (Basel)
Bravo-Oro A, Ugarte-Anchondo S, Martínez-Ruiz EO, Rodríguez-Aranda MDC, Reyes-Reyes A, García-Mendoza CI, Ortiz-Dosal LC, Rivera-Pérez E, Reyes-Reyes JA, Kolosovas-Machuca ES, Ortiz-Dosal A.   +10 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Shaping soft hydrogels into 3D, multiscale, perfusable models using multimodal printing. [PDF]

Biofabrication
Kunwar P, Poudel A, Aryal U, Geffert ZJ, Fougnier D, Narkar A, Zhang K, Filip A, Soman P.   +8 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Evaluation of Mode III Interlaminar Fracture Toughness of Laminated Composites

Science and Engineering of Composite Materials, 2008
Ogihara, Shinji
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A note on dislocation-based mode III gradient elastic fracture mechanics

Journal of the Mechanical Behavior of Materials, 2015
Mousavi S. Mahmoud, Aifantis E.C.
doaj   +1 more source

Characterization of human milk oligosaccharides from Chinese mothers and their association with delivery mode and infant eczema. [PDF]

Front Nutr
Jiang S, Huang F, Hartweg M, Chen M, Wang S, Yan J, Ren X, Li Q, Fu Q, Silva Zolezzi I, Thakkar SK, Yu K, Binia A, Austin S, Sprenger N, Wang Y, Yang Z, Lai J, Monnard C.   +18 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Thin-Film-Engineered Self-Assembly of 3D Coaxial Microfluidics with a Tunable Polyimide Membrane for Bioelectronic Power. [PDF]

Nanomicro Lett
Egunov AI, Tang H, Saenz PE, Karnaushenko DD, Luo Y, Zhong C, Wang X, Huang Y, Fedorov P, Merces L, Zhu M, Karnaushenko D, Schmidt OG.   +12 more
europepmc   +1 more source