Results 91 to 100 of about 2,782,184 (305)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Ensemble All Time-Scale Decomposition Method and Its Application in Bevel Gear Fault Diagnosis
SensorsAll time-scale decomposition (ATD) is a non-parametric adaptive signal decomposition method, which relies on zero-crossing points and extreme points to jointly construct the baseline, achieving the suppression of modal mixing caused by the proximity of ...
Zhengyang Cheng +4 more
doaj +1 more source
Estimation of the Mode Function for e-mixing Observations [PDF]
, 2012 It is shown that the (empirically determined) mode of the kernel estimate uniformly converges to the conditional mode function under the rho -mixing condition over an increasing sequence of compact sets which increases to IR ...
Arfi, Mounir
core
A self-mixing laser sensor design with an extended kalman filter for optimal online structure analysis and damping evaluation [PDF]
, 2007 We have developed a new algorithm based on the extended Kalman filter, in order to improve the resolution of an optical displacement sensor. This new non contact sensor which provides vibration measurement with a very good accuracy might be used for ...
Bès, Caroline +4 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Deep Neural Network-Based Empirical Mode Decomposition for Motor Imagery EEG Classification
IEEE Transactions on Neural Systems and Rehabilitation EngineeringMotor imagery refers to the brain’s response during the mental simulation of physical activities, which can be detected through electroencephalogram (EEG) signals.
Hyunsoo Yu +5 more
doaj +1 more source
, 2022 The supplemental document contains more details on the roundtrip matrix for-malism, the fitting produce of the mode mixing ratio, AFM measurements and additional measurements on other ...
Martin van Exter (9512939) +1 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source