Results 221 to 230 of about 2,890,573 (296)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Near-White Circularly Polarized Luminescence by Color Mixing Utilizing Surface-Fluorophore-Modified Cellulose Nanocrystals in Composite Films. [PDF]

Chemistry
Shah A, Lerch TG, Acharjee G, Rohaley GAR, Akhter S, Kamuti NM, Gowda A, Williams RA, Hegmann E, Prévôt ME, Hegmann T.   +10 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

A System for Retrofitting Conventional MRI Systems for Simultaneous Multinuclear MRI/MRS. [PDF]

NMR Biomed
Hou J, Bauer C, Touchet-Valle E, McDougall MP, Wright SM.   +4 more
europepmc   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Deep Eutectic Solvent as Dual Solvent-Catalyst for Efficient Starch Esterification With Vinyl Laurate via Reactive Extrusion. [PDF]

ChemSusChem
Bouzidi S, Najahi A, Lévêque JM, Chaud P, Hugenell F, Magnin A, Molina-Boisseau S, Putaux JL, Boufi S.   +8 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Research on Signal Denoising of Pumped-Storage Units Based on Parameter-Adaptive VMD and Wavelet Thresholding. [PDF]

Sensors (Basel)
Li T, Wu Y, Pei F.
europepmc   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Mitigating aviation's environmental impact through alternative fuels and cleaner engines. [PDF]

Sci Adv
Dischl R, Sauer D, Voigt C, Märkl R, Neumann G, Bräuer T, Harlaß T, Kaufmann S, Scheibe M, Roiger A, Seeliger K, Renard C, Roche A, Eckel G.   +13 more
europepmc   +1 more source