Results 41 to 50 of about 185,420 (264)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Mixed Modes of Innovation [PDF]

OECD Science, Technology and Industry Working Papers, 2012
This study uses exploratory data analysis techniques to develop typologies of innovation modes or strategies for groups of firms. Analysing micro-level survey data from 18 countries we identify five innovation modes. The coherence and relevance of the innovation modes is tested by using them as explanatory factors in equations explaining economic ...
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Variable Filtered-Waveform Variational Mode Decomposition and Its Application in Rolling Bearing Fault Feature Extraction

Entropy
Variational Mode Decomposition (VMD) serves as an effective method for simultaneously decomposing signals into a series of narrowband components. However, its theoretical foundation, the classical Wiener filter, exhibits limited adaptability when applied
Nuo Li, Hang Wang
doaj   +1 more source

Effect of Bottom Blowing Mode on Fluid Flow and Mixing Behavior in Converter

Metals, 2022
Bottom blowing agitation plays a crucial role in improving the reaction kinetics condition of molten bath during the steelmaking process. Herein, the influence of bottom blowing mode on the flow and mixing characteristics of molten bath and the abrasion ...
Jiankun Sun, Jiangshan Zhang, Wenhui Lin, Xiaoming Feng, Qing Liu   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Effects of mixing modes on nonresponse and measurement error in an economic panel survey

Journal for Labour Market Research, 2023
Numerous panel surveys around the world use multiple modes of data collection to recruit and interview respondents. Previous studies have shown that mixed-mode data collection can improve response rates, reduce nonresponse bias, and reduce survey costs ...
Joseph W. Sakshaug, Jonas Beste, Mark Trappmann   +2 more
doaj   +1 more source

Degeneration of flow pattern in acousto-elastic flow through sharp-edge microchannels

Ultrasonics Sonochemistry, 2023
Acoustic streaming (AS) is the steady time-averaged flow generated by acoustic field, which has been widely used in enhancing mixing and particle manipulation.
Yuwen Lu, Wei Tan, Zhifang Liu, Shuoshuo Mu, Guorui Zhu   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source