Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
The Impact of Mixing and Ca(OH)2 Suspension Concentration on Hydroxyapatite Synthesis
The effects of lime concentration together with mixing conditions on synthesis of hydroxyapatite is being ...
Sokolova, Marina +2 more
core
Numerical Investigation of Differential Speed Coupling Mechanisms in a 600 L Eccentric Four-Shaft Mixer for High-Viscosity Polyurethane Adhesives. [PDF]
Materials (Basel)Luo Y, Fan L, He B, Fan X, Qiu F, Liu R.
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Terahertz dynamics at the actinide frontier: linking low-frequency vibrations, electronic structure, and bonding in molecular uranium complexes. [PDF]
Chem SciPittalis M +8 more
europepmc +1 more source
, 2006 However, the availability in the 1950s of large-scale mechanical cooling, along with other technologies such as curtain walls and fluorescent lighting, led to the more common building forms we see today in North America—typically all-glass, flush-skin buildings with large floor plates and no operable windows.Our technological capabilities allow ...
openaire +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Effects of carbonation methods on mechanical behavior and carbonation mechanisms of coal gangue based geopolymer stabilized saline soil. [PDF]
Sci RepYang X, Ren Y, Cui R, Li W, Liu J.
europepmc +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
AI models of unstable flow exhibit hallucination. [PDF]
Sci RepWibawa R, Jha B.
europepmc +1 more source