Results 91 to 100 of about 2,884,392 (297)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Aerodynamic Control and Mixing with Ramp Injection [PDF]

open access: yes, 2005
Experiments have been conducted in the GALCIT Supersonic Shear Layer Facility (S3L) to investigate the behaviour of a flow and geometry with many features that are potentially useful for a Supersonic Combustion Ramjet (SCRAMJET) engine - a recirculation ...
Johnson, Michael Bernard
core   +1 more source

Deep Neural Network-Based Empirical Mode Decomposition for Motor Imagery EEG Classification

open access: yesIEEE Transactions on Neural Systems and Rehabilitation Engineering
Motor imagery refers to the brain’s response during the mental simulation of physical activities, which can be detected through electroencephalogram (EEG) signals.
Hyunsoo Yu   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

A New Method of Wind Turbine Bearing Fault Diagnosis Based on Multi-Masking Empirical Mode Decomposition and Fuzzy C-Means Clustering

open access: yesChinese Journal of Mechanical Engineering, 2019
Based on Multi-Masking Empirical Mode Decomposition (MMEMD) and fuzzy c-means (FCM) clustering, a new method of wind turbine bearing fault diagnosis FCM-MMEMD is proposed, which can determine the fault accurately and timely.
Yongtao Hu   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

All-optical mode conversion via spatially multimode four-wave mixing

open access: yesNew Journal of Physics, 2016
We experimentally demonstrate the conversion of a Gaussian beam to an approximate Bessel–Gauss mode by making use of a non-collinear four-wave mixing (4WM) process in hot atomic vapor.
Onur Danaci   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

A new definition of mixing and segregation: Three dimensions of a key process variable [PDF]

open access: yes, 2009
Although a number of definitions of mixing have been proposed in the literature, no single definition accurately and clearly describes the full range of problems in the field of industrial mixing.
Aubin, Joelle   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

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