Results 101 to 110 of about 168,707,534 (305)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Communal-Photosynthesis Metaphor: Autobiographical Action-Research Journeys and Heuristic-Action-Learning Frameworks of Living Educational Theories

, 2015
This article provides a creative analysis of reflective thought processes grounded in the systemic thinking of an autobiographical account of action-research journeys from the context of action-learning experiences that led to the discovery of the ...
Tetteh, Emmanuel Nii Ayikwei
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Action learning, action research: Towards greater collaboration amongst networks

, 2018
Recent conversations with a variety of action learning and action research practitioners around the world have identified a growing desire for collaboration between networks.
Bradley, Colin
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Action research on action research: A facilitator’s account

, 2012
This article describes research conducted by a facilitator of a statewide action research network, the Wyoming Teacher Policy Institute (WTPI).
Trent, Allen
core  

Collaborative writing as action research: A story in the making

, 2021
A small, transnational group of action researchers came into a collaborative writing venture as part of a broader research inquiry. The inquiry was looking into the role of action research publications in manifesting action research in the world.
Bessemer, Yedida, Vaartjes, Vicki, Goff, Susan, Austin, Diana, Hill, Geof, Orr, Liz   +5 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A School’s Own Adaptation of Action Learning: From a Traditional Action Learning Project, to a Whole School Action Learning Project, to a Professional Learning Culture.

, 2017
Action Learning finds its basis in experimental learning theory. For the staff at Western Public school Action Learning and experimental learning underpin their success of the use of Action Learning within their school.
Mehorter, Bronwyn Ruth
core