Results 161 to 170 of about 168,707,534 (305)

Man standing next to a spillway on small dam, in front of pile of previously floating debris.

, 2015
The Eastern slopes of the Andes in North Peru are among the least developed parts of the country with the majority of people living in remote villages with little or no access to grid electricity.
Practical Action Peru
core  

Native Label-Free Spectral Biochemical Fingerprinting of an Enveloped Mammalian RNA Virus Reveals Mode of Action of a Virucidal Drug. [PDF]

Small Methods
Rajnovic D, Matroodi F, Almehmadi LM, Carletti T, Gessini A, Lednev IK, Masciovecchio C, Marcello A, Rossi B.   +8 more
europepmc   +1 more source

Mode of action of vancomycin

Journal of Pharmacy and Pharmacology, 1964
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Developing environmental citizenship on campus through Action Research

, 2015
This study was designed to refine understanding of the influence of environmental education on the development of thought processes, on moral awareness and on students' ability to act as environmental citizens.
Avriel-Avni, Noa
core  

Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials. [PDF]

ACS Infect Dis
Maluf SEC, Mendes GR, Moura IMR, de Souza GE, Valdes TA, Bonatto V, Oliveira GS, Aguiar ACC, Gazarini ML, Puhl AC, Monakhova N, Lepioshkin A, Makarov V, Lane TR, Raman R, Campolina GAS, Barbosa CS, Ferreira ADS, Teles CBG, Pereira DB, Barros RRM, Benavente ED, Ekins S, Guido RVC.   +23 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Long view of a concrete channel carrying water to a turbine.

, 2015
The Eastern slopes of the Andes in North Peru are among the least developed parts of the country with the majority of people living in remote villages with little or no access to grid electricity.
Practical Action Peru
core  

Engineering Penicillium expansum antifungal proteins unveils new clues about their mode of action. [PDF]

Appl Microbiol Biotechnol
Giner-Llorca M, Gallego Del Sol F, de Ovalle S, Thomson DD, Bignell EM, Marina A, Marcos JF, Manzanares P.   +7 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source