Results 111 to 120 of about 1,155,111 (306)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Profile of Patients with Post Partum Hemorrhage in Dr. Soetomo Hospital, Surabaya, January 2011 - December 2013 [PDF]

, 2016
Objectives: To recognize profile of patients with post partum haemorrhage in Dr. Soetomo Hospital, Surabaya, from January 2011 to December 2013.Materials and Methods: This was a descriptive study using secondary data from medical records of patients with
Akbar, A. (Aldika), Azyati, M. (Mazaya), Sudarno, S. (Sudarno)   +2 more
core  

Period spacings in red giants II. Automated measurement

, 2016
The space missions CoRoT and Kepler have provided photometric data of unprecedented quality for asteroseismology. A very rich oscillation pattern has been discovered for red giants, including mixed modes that are used to decipher the red giants interiors.
Mosser, B., Samadi, R., Vrard, M.
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The effects of intravenous hydration regimens in nulliparous women undergoing induction of labor: A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica
Introduction Labor is both a physiological and physical activity that requires energy expenditure by the woman. Despite this, women are often fasted in labor, with hydration requirements addressed predominantly by intravenous therapy.
Lauren Kearney, Susannah Brady, Nicole Marsh, Miranda Davies‐Tuck, Rachael Nugent, Victoria Eley   +5 more
doaj   +1 more source

Performance of sleep-mode mechanisms under light-traffic conditions [PDF]

, 2009
Modem standards for wireless telecommunication, such as IEEE 802. 16s (WiMAX"), foresee in several power-saving mechanisms. One of the main mechanisms is sleep-mode operation, which allows the mobile device to switch off the antenna during a negotiated ...
Bruneel, Herwig, De Turck, Koen, Fiems, Dieter, Wittevrongel, Sabine   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Impact of Delivery Mode on Neonatal Outcomes in Extremely Preterm Infants Born at 22 + 0 to 25 + 6 Weeks of Gestation

Medicina
Background and Objectives: Extremely preterm infants (
Filiz Markfeld-Erol, Martin Kuntz, Valeria Laufs, Susanne Tippmann, Ingolf Juhasz-Böss, Annette Hasenburg, Joscha Steetskamp   +6 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source