Results 71 to 80 of about 6,085,060 (269)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A statutory compensation model for AI training based on the copy levies payment framework [PDF]

Annales Scientia Politica
The article addresses the lack of adequate legal mechanisms regulating the use of copyrighted works in the training of artificial intelligence (AI) algorithms, particularly in the context of copyright law.
Andrzej Madera
doaj  

Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

Frontiers in Pharmacology
Immune inflammation is one of the main factors in the pathogenesis of depression. It is an effective and active way to find more safe and effective anti-inflammatory depressant drugs from plant drugs. The purpose of this study is to explore the potential
Dan Su, Qianmin Li, Xin Lai, Yonggui Song, Huizhen Li, Zhifu Ai, Qi Zhang, Wenxiang Shao, Ming Yang, Ming Yang, Genhua Zhu   +10 more
doaj   +1 more source

Model-Based Clustering

, 2019
Mixture models extend the toolbox of clustering methods available to the data analyst. They allow for an explicit definition of the cluster shapes and structure within a probabilistic framework and exploit estimation and inference techniques available for statistical models in general.
openaire   +3 more sources

The Role of Model-Based Testing [PDF]

, 2008
This position paper gives an overview of model-based testing and discusses how it might fit into the proposed grand challenge for a program verifier.
openaire   +3 more sources

Model-based annotation of coreference

CoRR, 2019
Humans do not make inferences over texts, but over models of what texts are about. When annotators are asked to annotate coreferent spans of text, it is therefore a somewhat unnatural task. This paper presents an alternative in which we preprocess documents, linking entities to a knowledge base, and turn the coreference annotation task -- in our case ...
Aralikatte, Rahul, Søgaard, Anders
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A high-resolution 7 Tesla resting-state fMRI dataset optimized for studying the subcortex

Data in Brief
To achieve a comprehensive understanding of spontaneous brain dynamics in humans, in vivo acquisition of intrinsic activity across both cortical and subcortical regions is necessary. Here we present advanced whole-brain, resting-state functional magnetic
Josephine M. Groot, Steven Miletic, Scott J.S. Isherwood, Desmond H.Y. Tse, Sarah Habli, Asta K. Håberg, Pierre-Louis Bazin, Matthias Mittner, Birte U. Forstmann   +8 more
doaj   +1 more source