Results 41 to 50 of about 12,438,139 (288)

Why and When Are Evidence‐Based Interventions Adopted in Paediatric Supportive Care? A Qualitative Exploration of the Determinants of Photobiomodulation Implementation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie, Kara A. Gray‐Burrows, Peter F. Day, Bob Phillips, Carl A. Thompson   +4 more
wiley   +1 more source

Gaussian process emulators for the undrained bearing capacity of spatially random soils using cell-based smoothed finite element method

Journal of Rock Mechanics and Geotechnical Engineering
In this paper, we propose a novel probabilistic method for predicting the undrained bearing capacity of spatially variable soils. Our approach combines a Gaussian process regression (GPR)-based surrogate model with random cell-based smoothed finite ...
H.C. Nguyen, X. He, M. Nazem, X. Chen, H. Xu, R. Sousa, J. Kowalski   +6 more
doaj   +1 more source

Model-Based Methods to Produce Greener Metakaolin Composite Concrete

Applied Sciences, 2021
Metakaolin is reactive and is widely used in the modern concrete industry. This study presents an integrated strength–sustainability evaluation framework, which we employed in the context of metakaolin content in concrete.
Ki-Bong Park, Run-Sheng Lin, Yi Han, Xiao-Yong Wang   +3 more
doaj   +1 more source

Multi-center clinical trials: Randomization and ancillary statistics

, 2008
The purpose of this paper is to investigate and develop methods for analysis of multi-center randomized clinical trials which only rely on the randomization process as a basis of inference.
Zelen, Marvin, Zheng, Lu
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Uncertainty Quantification in Fatigue Crack Growth Prognosis [PDF]

International Journal of Prognostics and Health Management, 2011
This paper presents a methodology to quantify the uncertainty in fatigue crack growth prognosis, applied to structures with complicated geometry and subjected to variable amplitude multi-axial loading.
Shankar Sankararaman, You Ling, Christopher Shantz, Sankaran Mahadevan   +3 more
doaj  

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Quantitative Set-Based Design to Inform Design Teams

Applied Sciences, 2021
System designers, analysts, and engineers use various techniques to develop complex systems. A traditional design approach, point-based design (PBD), uses system decomposition and modeling, simulation, optimization, and analysis to find and compare ...
Eric Specking, Nicholas Shallcross, Gregory S. Parnell, Edward Pohl   +3 more
doaj   +1 more source

A Model-Based Method for Gene Dependency Measurement

PLoS ONE, 2012
Many computational methods have been widely used to identify transcription regulatory interactions based on gene expression profiles. The selection of dependency measure is very important for successful regulatory network inference. In this paper, we develop a new method-DBoMM (Difference in BIC of Mixture Models)-for estimating dependency of gene by ...
Qing Zhang, Xiaodan Fan, Yejun Wang, Mingan Sun, Samuel S M Sun, Dianjing Guo   +5 more
openaire   +4 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source