Results 91 to 100 of about 9,013,912 (355)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Logic Negation with Spiking Neural P Systems
, 2019 Nowadays, the success of neural networks as reasoning systems is doubtless. Nonetheless, one of the drawbacks of such reasoning systems is that they work as black-boxes and the acquired knowledge is not human readable.
Borrego-Díaz, Joaquín +2 more
core +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
ComputersModern custom machine construction and automation projects face pressure to shorten innovation cycles, reduce durations, and manage growing system complexity.
Roland Wölfle +2 more
doaj +1 more source
A Diagram Is Worth A Dozen Images
, 2016 Diagrams are common tools for representing complex concepts, relationships and events, often when it would be difficult to portray the same information with natural images.
B Alexe +13 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Applied SciencesTable-based question answering (TableQA) has emerged as an important task in natural language processing, yet existing models face challenges in handling complex reasoning and mitigating hallucinations, especially when dealing with diverse table ...
Jianbin Zhao +8 more
doaj +1 more source
The battery for assessment of clinical reasoning in the Olympiad for medical sciences students [PDF]
مجله ایرانی آموزش در علوم پزشکی, 2011 Clinical reasoning is not only a critical skill in medicine, but also central to the clinical practice. Considering that there is no method of assessing clinical reasoning based on the theoretical framework of medical expertise research, we could ...
Alireza Monajemi +8 more
doaj
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source