Results 141 to 150 of about 9,013,912 (355)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

An Agent Based Market Design Methodology for Combinatorial Auctions [PDF]

open access: yes
Auction mechanisms have attracted a great deal of interest and have been used in diverse e-marketplaces. In particular, combinatorial auctions have the potential to play an important role in electronic transactions.
Gyoo Gun Lim, Jinho Choi, Kun Chang Lee
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Approach of service evaluation based on trust reasoning for cloud computing

open access: yesTongxin xuebao, 2011
The credibility reasoning and deducing of SC and SP were proposed,which were mainly in the direct trust re-lationship established in interactive process among service entities,the public credibility of the feedback system as a sup-plement.The model used ...
HU Chun-hua1   +3 more
doaj   +2 more sources

Spatio-Temporal Graph Convolution Transformer for Video Question Answering

open access: yesIEEE Access
Currently, video question answering (VideoQA) algorithms relying on video-text pretraining models employ intricate unimodal encoders and multimodal fusion Transformers, which often lead to decreased efficiency in tasks such as visual reasoning ...
Jiahao Tang   +6 more
doaj   +1 more source

Dynamics of Inductive Inference in a Unified Framework [PDF]

open access: yes
We present a model of inductive inference that includes, as special cases, Bayesian reasoning, case-based reasoning, and rule-based reasoning. This unified framework allows us to examine, positively or normatively, how the various modes of inductive ...
David Schmeidler   +2 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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