Results 181 to 190 of about 9,013,912 (355)

Making Chatbots more human: deep reasoning large language models in ophthalmology. [PDF]

Front Med (Lausanne)
Lin X, Yang Y, Ren Y.
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Large Language Model–Based Assessment of Clinical Reasoning Documentation in the Electronic Health Record Across Two Institutions: Development and Validation Study

Verity Schaye, David J DiTullio, Benedict Guzman, Scott Vennemeyer, Hanniel Shih, Ilan Reinstein, Danielle Weber, Abbie Goodman, Danny T Y Wu, Daniel J. Sartori, Sally A. Santen, Larry D. Gruppen, Yindalon Aphinyanaphongs, Jesse Burk‐Rafel   +13 more
openalex   +1 more source

A Novel Fault Detection Model Based on Atanassov’s Interval-Valued Intuitionistic Fuzzy Sets, Belief Rule Base and Evidential Reasoning

, 2019
Qianlei Jia, Jiayue Hu, Weiguo Zhang
openalex   +1 more source

Micro Fault Diagnosis of Driving Motor Bearings Based on Multi-Residual Neural Networks and Evidence Reasoning Rule. [PDF]

Entropy (Basel)
Zhang A, Tang L, Hu G.
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

HybridSense-LLM: A Structured Multimodal Framework for Large-Language-Model-Based Wellness Prediction from Wearable Sensors with Contextual Self-Reports. [PDF]

Bioengineering (Basel)
Yu CH, Masum M.
europepmc   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Transforming wearable data into personal health insights using large language model agents. [PDF]

Nat Commun
Merrill MA, Paruchuri A, Rezaei N, Kovacs G, Perez J, Liu Y, Schenck E, Hammerquist N, Sunshine J, Tailor S, Ayush K, Su HW, He Q, McLean CY, Malhotra M, Patel S, Zhan J, Althoff T, McDuff D, Liu X.   +19 more
europepmc   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source