Results 121 to 130 of about 6,641,478 (335)

Transdisciplinary model-based systems engineering in the development of the Ruminant Farm Systems model

Frontiers in Sustainability
This study adopts a transdisciplinary model-based systems engineering (MBSE) approach to support the development of the Ruminant Farm Systems (RuFaS) model, an advanced on-farm decision support tool.
Haowen Hu, Clifford A. Whitcomb, Thomas E. Ploetz, Kristan F. Reed, Kristan F. Reed   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Optimizing additive manufacturing workflows using model-based systems engineering

Results in Engineering
Additive Manufacturing (AM) is a transformative technology enabling the production of complex geometries with reduced waste and lead times. However, optimizing AM workflows involves addressing challenges such as design validation, process parameters, and
Mohamed Amine Daoud, Khadija Bekkay Haouari, Meriem Hayani Mechkouri, Amine Ennawaoui, Hicham El hadraoui, Ilias Naser, Mustapha Ouardouz, Kamal Reklaoui   +7 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Ensuring Semantic Consistency in SysML v2 Models Through Metamodel-Driven Validation

IEEE Access
Model-Based Systems Engineering (MBSE) relies on formal models for system lifecycle management, supporting model coherence and efficient reuse of components.
Eduardo Cibrian, Jose Olivert-Iserte, Carlos Diez-Fenoy, Roy Mendieta, Juan Llorens, Jose Maria Alvarez-Rodriguez   +5 more
doaj   +1 more source

Model-Based Systems Engineering Pilot Program at NASA Langley [PDF]

, 2012
NASA Langley Research Center conducted a pilot program to evaluate the benefits of using a Model-Based Systems Engineering (MBSE) approach during the early phase of the Materials International Space Station Experiment-X (MISSE-X) project. The goal of the
Infeld, Samatha I., Murphy, Douglas G., Vipavetz, Kevin G.   +2 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Model-Based Approach to Engineering Resilience in Multi-UAV Systems

Systems, 2019
Multi-UAV Operations are an area of great interest in government, industry, and research community. In multi-UAV operations, a group of unmanned aerial vehicles (UAVs) are deployed to carry out missions such as search and rescue or disaster relief.
Edwin Ordoukhanian, Azad M. Madni
doaj   +1 more source

THE MODEL AND METHOD OF SCADA DIAGNOSTICS AS AN OBJECT WITH PARTIALLY DEFINED PARAMETERS [PDF]

, 2017
Modern SCADA are widely spread all over the world to control technological processes in different industries such as power engineering, military, transport, etc.
Syrotkina, O, Сироткіна, Олена Ігорівна   +1 more
core   +2 more sources