Results 61 to 70 of about 230,174 (255)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Real-Time Model-Checking: Parameters everywhere [PDF]
Logical Methods in Computer Science, 2007 In this paper, we study the model-checking and parameter synthesis problems of the logic TCTL over discrete-timed automata where parameters are allowed both in the model (timed automaton) and in the property (temporal formula). Our results are as follows.
Veronique Bruyere, Jean-Francois Raskin
doaj +1 more source
Mathematics, 2023 Social networks have received considerable attention from the modal logic community. In this article, we study and characterize one of the most important principles in the field of social networks.
Xiling Luo
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Software Model Checking via Large-Block Encoding [PDF]
, 2009 The construction and analysis of an abstract reachability tree (ART) are the basis for a successful method for software verification. The ART represents unwindings of the control-flow graph of the program.
Alberto Griggio +5 more
core +5 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Heliyon, 2023 Problem: The congenial of the imputation model is crucial for valid statistical inferences. Hence, it is important to develop methodologies for diagnosing imputation models.
Mingyang Cai +2 more
doaj +1 more source
Model checking programmable router configurations [PDF]
, 2010 Programmable networks offer the ability to customize router behaviour at run time, thus increasing flexibility of network administration. Programmable network routers are configured using domain-specific languages. In this paper, we describe our approach
Emmerich, W, Mascolo, C, Zanolin, L
core
Lazy Probabilistic Model Checking without Determinisation [PDF]
, 2015 The bottleneck in the quantitative analysis of Markov chains and Markov decision processes against specifications given in LTL or as some form of nondeterministic B\"uchi automata is the inclusion of a determinisation step of the automaton under ...
Hahn, Ernst Moritz +4 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source