Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
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wiley +1 more source
A city-scale optimization framework for biomass-to-clean-energy transitions: The KAMPALA-TIMES model. [PDF]
iScienceKimuli I, Kirabira JB, Mujjuni F.
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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Five views on the foundations of data science. [PDF]
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Time to accelerate rare disease research: AI-powered in silico trials, digital twin-driven RCTs and decision-grade real-world evidence. [PDF]
Br J Clin PharmacolBelančić A +5 more
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Controlled environment agriculture as urban infrastructure: advancing a public agenda for spatial equity. [PDF]
Urban InformRao X +4 more
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Intrinsic elaboration of prefrontal modularity: a dual-control model of axon bundling and synaptic docking. [PDF]
Front NeuroanatYamamori T, Watakabe A, Skibbe H.
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Identifying systemic risks and mitigation strategies of artificial intelligence in agriculture: from social-technical-ecological systems framework. [PDF]
Front Plant SciYuan Y, Sun Y.
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Beyond Temperature: Relative Humidity Systematically Shifts Juvenile Thermal Performance and Projected Population Growth in a Malaria Vector. [PDF]
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