Results 101 to 110 of about 46,693,128 (348)

The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration

Journal of Neuroinflammation, 2019
Background Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into pentoses and generates ...
Dezhen Tu, Yun Gao, Ru Yang, Tian Guan, Jau-Shyong Hong, Hui-Ming Gao   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Implementation determinants of risk-stratified gestational diabetes mellitus screening in community-based women’s peer groups in rural western Kenya

BMC Pregnancy and Childbirth
Background Gestational Diabetes Mellitus (GDM) contributes to maternal and neonatal complications and is a growing concern in Kenya. The 2-hour oral glucose tolerance test (OGTT) is recommended to diagnose GDM between 24 and 28 weeks of pregnancy, but ...
Rachel Ogumbo, Violet Naanyu, Laura Ruhl, James Akiruga, Evelyn Kaluhi, Sheilah Chelagat, Hector Nyaboga, Sonak Pastakia   +7 more
doaj   +1 more source

Generation and characterization of a tamoxifen-inducible lineage tracing tool Cd2-P2A-CreERT2 knock-in mice

Frontiers in Immunology
IntroductionThe new targeted gene editing technologies, such as the CRISPR/Cas system, enable researchers to insert or delete genes at targeted loci efficiently.
Yang Guo, Mengyan Zhu, Zhilan Yu, Qing Li, Yanjuan Chen, Lei Ci, Ruilin Sun, Ruling Shen   +7 more
doaj   +1 more source

A Note on Model Complete Models and Generic Models [PDF]

Proceedings of the American Mathematical Society, 1972
We prove that there are many maximum model complete (= generic) models, and that there exists an (uncountable) theory with no generic models.
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Paris on Stage: 1889-1914 [exhibition]; Vespasienne (pissoir) Model

, 2013
Information label with photograph of original, in situ; Scale model, part of the Paris on Stage: 1889-1914 exhibition held June 19, 2013 to February 23, 2014.
unknown (Canadian model maker)
core  

Sub-series 2: Publications

, 2017
Bimonthly magazine discussing topics related to aviation and model airplane engines including collecting, restoring, maintaining, and identifying engines, along with ...
The Model Museum, Dannels, Timothy J.
core   +1 more source

Sensitivity of the 2018 UK summer heatwave to local sea temperatures and soil moisture

Atmospheric Science Letters, 2020
The impact of local climate conditions on air temperatures during a hot summer period over the United Kingdom in 2018 is studied using simple sensitivity experiments with a state‐of‐the‐art regional numerical weather prediction system.
Jon C. Petch, Chris J. Short, Martin J. Best, Mark McCarthy, Huw W. Lewis, Simon B. Vosper, Mark Weeks   +6 more
doaj   +1 more source