Results 251 to 260 of about 58,575,561 (400)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Binder jetting additive manufacturing of silicon carbide ceramics: Development of bimodal powder feedstocks by modeling and experimental methods

, 2020
Wenchao Du, Mrityunjay Singh, Dileep Singh   +2 more
openalex   +2 more sources

Comparison of Lithium-Ion Battery Models for Simulating Storage Systems in Distributed Power Generation [PDF]

, 2019
Hartmut Hinz
openalex   +1 more source

Bayesian measures of model complexity and fit

, 2002
D. Spiegelhalter, N. G. Best, B. Carlin, A. van der Linde   +3 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Brain Amyloid Plaque Levels Affect Clinical Progression in Alzheimer Disease: Assessment of Amyloid PET and Change in CDR-SB Utilizing Semi-Mechanistic Model. [PDF]

CPT Pharmacometrics Syst Pharmacol
Bhagunde P, Penner N, Willis BA, Bell R, Charil A, Irizarry MC, Hersch S, Reyderman L.   +7 more
europepmc   +1 more source

Deep learning inter-atomic potential model for accurate irradiation damage simulations [PDF]

, 2019
Hao Wang, Xun Guo, Linfeng Zhang, Handong Wang, Jianming Xue   +4 more
openalex   +1 more source

Mathematical model for studying genetic variation in terms of restriction endonucleases.

Proceedings of the National Academy of Sciences of the United States of America, 1979
M. Nei, W. -. Li
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Combining Aggregate Data and Individual Patient Data in Model-Based Meta-Analysis: An Illustrative Case Study of Tofacitinib in Rheumatoid Arthritis Patients. [PDF]

CPT Pharmacometrics Syst Pharmacol
Pham TN, Largajolli A, Sardu ML, Maringwa J, Zierhut ML, Cheung SYA.   +5 more
europepmc   +1 more source