Results 271 to 280 of about 55,098,274 (381)
Analysis and simulation of a novel stochastic RNA silencing model. [PDF]
Sci RepAhmed R, Elshehabey HM.
europepmc +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Efficient approximations of transcriptional bursting effects on the dynamics of a gene regulatory network. [PDF]
J R Soc InterfaceKursawe J, Moneyron A, Galla T.
europepmc +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Preoperative Prediction Models for 30-Day All-Cause Mortality After Mitral Valve Repair in Dogs: A Single-Center Retrospective Cohort Study. [PDF]
J Vet Intern MedFurusato S +5 more
europepmc +1 more source
Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?
Molecular Oncology, EarlyView.Chen‐xi Li, Zhong‐cheng Gong
wiley +1 more source
Is Bigger Better? How Art Museum Expansions Impact Institutional Mission [PDF]
, 2001 Model, Barbara
core +3 more sources
Automated model refinement using perturbation-observation pairs. [PDF]
NPJ Syst Biol ApplPark KH, Rozum JC, Albert R.
europepmc +1 more source