Results 301 to 310 of about 35,199,249 (362)

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Enhanced metastasis risk prediction in cutaneous squamous cell carcinoma using deep learning and computational histopathology. [PDF]

NPJ Precis Oncol
Peleva E, Chen Y, Finke B, Rizvi H, Healy E, Lai C, Craig P, Rickaby W, Schoenherr C, Nourse C, Proby C, Inman GJ, Leigh IM, Harwood CA, Wang J.   +14 more
europepmc   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies

Molecular Oncology, EarlyView.
We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová   +14 more
wiley   +1 more source

The mediating role of hope in the relationship between purpose in life and anxiety: A cross-cultural analysis in university students. [PDF]

PLoS One
Moreno-Montero E, Moreta-Herrera R, Rodas JA, Cuesta-Andaluz E, Puerta-Cortés DX, Ferrufino-Borja D, Oleas D, Gismondi Diaz R.   +7 more
europepmc   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Development and validation of supervised machine learning multivariable prediction models for the diagnosis of Pneumocystis jirovecii pneumonia using nasopharyngeal swab PCR in adults in a low-HIV prevalence setting. [PDF]

Int Health
Chew R, Woods ML, Paterson DL.
europepmc   +1 more source

A student academic performance prediction model based on the interval belief rule base. [PDF]

Sci Rep
Zhou W, Li Y, Li J, Zhang T, Duan X, Ma N, Wang Y.   +6 more
europepmc   +1 more source

The Association Between Gamma-Glutamyl Transferase and Metabolic Syndrome and Its Components Among Adolescents Applying International Diabetes Federation (IDF) and Cook's Criteria. [PDF]

Endocrinol Diabetes Metab
Esmaeili F, Safiee S, Hasheminia M, Azizi F, Tohidi M, Hadaegh F.   +5 more
europepmc   +1 more source