Results 91 to 100 of about 69,021 (262)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

HD 206893 B at High Spectral Resolution with the Keck Planet Imager and Characterizer

The Astronomical Journal
We present an atmospheric characterization and orbital analysis of HD 206893 B, an exceptionally red, L/T-transition substellar companion in a multiplanetary system, via Keck Planet Imager and Characterizer (KPIC) high-resolution ( R ∼ 35,000) K- band ...
Ben Sappey, Quinn Konopacky, Clarissa R. Do Ó, Travis Barman, Jean-Baptiste Ruffio, Jason Wang, Christopher A. Theissen, Luke Finnerty, Jerry Xuan, Katelyn Hortsman, Dimitri Mawet, Yapeng Zhang, Julie Inglis, Nicole L. Wallack, Aniket Sanghi, Ashley Baker, Randall Bartos, Geoffrey A. Blake, Charlotte Z. Bond, Benjamin Calvin, Sylvain Cetre, Jacques-Robert Delorme, Greg Doppmann, Daniel Echeverri, Michael P. Fitzgerald, Chih-Chun Hsu, Nemanja Jovanovic, Joshua Liberman, Ronald A. López, Emily C. Martin, Evan Morris, Jacklyn Pezzato-Rovner, Caprice L. Phillips, Garreth Ruane, Tobias Schofield, Andrew Skemer, Taylor Venenciano, J. Kent Wallace, Ji Wang, Peter Wizinowich, Yinzi Xin   +40 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Fishing ship trajectory prediction considering trajectory behavior characteristics

Journal of Ocean Engineering and Science
Understanding and accurately predicting the trajectory changes of fishing ships is of great significance for effectively preventing collisions between merchant and fishing ships and enhancing the safety supervision of fishing ships.
Jianwen Ma, Zhaojun Chen, Jingru Yuan, Jinyu Li, Guoxin Liu   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Interferometric view into RT Pav’s long secondary period

Astronomy & Astrophysics
Context. Long secondary periods (LSPs) occur in roughly one third of evolved stars, yet their origin remains uncertain. Two leading hypotheses are oscillatory convective modes and a binary companion enshrouded in dust. Aims. We investigate the LSP in the
Courtney-Barrer B., Haubois X., Wood P., Dionese D., Decin L., Paladini C., El Mellah I., Defrère D., Ireland M.   +8 more
doaj   +1 more source