Results 41 to 50 of about 69,923,792 (250)

Le modèle coopératif comme source de résilience [PDF]

, 2020
Sur base d'une enquête menée auprès d'un échantillon de 100 coopératives en Région Wallonne, le webinaire vise à identifier les sources de résilience du modèle coopératif, en distinguant les atouts internes (ce qui favorise la résilience des entreprises ...
Mertens de Wilmars, Sybille, Kocovski, Flora   +1 more
core  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The influence of resilience and social support on mental health of older adults living in community: a cross-sectional study

BMC Psychology
Background Mental health is an important fundamental element of health that influences different dimensions of an older individual’s life. There are various factors that affect the mental health of older adults, such as resilience and social support ...
Ratchaneekorn Upasen, Weeraphol Saengpanya, Wanida Awae, Preedanan Prasitvej   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Transformation digitale et résilience organisationnelle des Petites et Moyennes Entreprises au Cameroun : importance des logiques entrepreneuriales [PDF]

Au regard de l’expansion dans le monde des crises de tout genre notamment celles sanitaires, sécuritaires et même naturelles (covid-19, guerre russo-ukrainienne, NOSO, Boko-Haram etc), de nombreuses économies demeurent fortement endommagées et cela ...
TCHINDA MONTCHIO Patrick Model, MENGADA NKOA Ignace Flavio, MBOUOLANG YIMPI Cédric, WANDJI Georges   +3 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

L'accompagnement vers la résilience

, 2020
Ouvrage de vulgarisationDes méthodes d'accompagnement favorisant la résilience de personnes ayant vécu des traumatismes sur le plan personnel, social ou scolaire ont été proposées par des chercheurs de l'équipe "Normes et valeurs" du laboratoire LISEC ...
Many, Holly, Chalmel, Loic
core   +3 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source