Results 71 to 80 of about 3,021,902 (318)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Agent‐Based Modeling of Alternative Futures in the British Land Use System

Earth's Future, 2022
Socio‐economic scenarios such as the Shared Socioeconomic Pathways (SSPs) have been widely used to analyze global change impacts, but representing their diversity is a challenge for the analytical tools applied to them. Taking Great Britain as an example,
C. Brown, B. Seo, P Alexander, V. Burton, E. A. Chacón‐Montalván, R. Dunford, M. Merkle, P. A. Harrison, R. Prestele, E. L. Robinson, M. Rounsevell   +10 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Promoting tissue repair with plant-derived compounds: evidence and mechanisms from zebrafish studies

Frontiers in Nutrition
The pursuit of strategies to enhance tissue repair is a central challenge in regenerative medicine, where plant-derived compounds offer immense therapeutic potential due to their multi-target, systems-level activities.
Xiang Meng, Xiang Meng, Xiang Meng, Xuting Song, Xuting Song, Xuting Song, Lixia Zhu, Lixia Zhu, Lixia Zhu, Yiming Wang, Yiming Wang, Yiming Wang, Xianghe Meng, Xianghe Meng, Yufang Tang, Yufang Tang, Kobil A. Bobokalonov, Min He, Min He, Min He, Mengmeng Sun, Mengmeng Sun, Mengmeng Sun, Meiying Jin, Meiying Jin   +24 more
doaj   +1 more source

Comparing Model Representations of Physiological Limits on Transpiration at a Semi‐Arid Ponderosa Pine Site

Journal of Advances in Modeling Earth Systems, 2022
Mechanistic representations of biogeochemical processes in ecosystem models are rapidly advancing, requiring advancements in model evaluation approaches.
Linnia R. Hawkins, Maoya Bassouni, William R. L. Anderegg, Martin D. Venturas, Stephen P. Good, Hyojung J. Kwon, Chad V. Hanson, Richard P. Fiorella, Gabriel J. Bowen, Christopher J. Still   +9 more
doaj   +1 more source

A model for clinical evaluation

Curationis, 1992
After grappling for years with the problems associated with clinical evaluation In nursing, and becoming increasingly am re of the importance of this aspect of the clinical teaching process, the researcher resolved to make an indepth study of the state of clinical evaluation in nursing. The study was undertaken in the second semester of1990.
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Simple Models Outperform More Complex Big‐Leaf Models of Daily Transpiration in Forested Biomes

Geophysical Research Letters, 2022
Transpiration makes up the bulk of total evaporation in forested environments yet remains challenging to predict at landscape‐to‐global scales. We harnessed independent estimates of daily transpiration derived from co‐located sap flow and eddy‐covariance
Ryan M. Bright, Diego G. Miralles, Rafael Poyatos, Stephanie Eisner   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source