Results 211 to 220 of about 2,381,965 (269)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Application of unified health large language model evaluation framework to In-Basket message replies: bridging qualitative and quantitative assessments. [PDF]

J Am Med Inform Assoc
Hong C, Chowdhury A, Sorrentino AD, Wang H, Agrawal M, Bedoya A, Bessias S, Economou-Zavlanos NJ, Wong I, Pean C, Li F, Pollak KI, Poon EG, Pencina MJ.   +13 more
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Social Acceptance of Smart Glasses in Health Care: Model Evaluation Study of Anticipated Adoption and Social Interaction. [PDF]

JMIR Form Res
Zuidhof N, Peters O, Verbeek PP, Ben Allouch S.   +3 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

TNFα-Induced Inflammation Model-Evaluation of Concentration and Passage-Dependent Effects on Bovine Chondrocytes. [PDF]

Int J Mol Sci
Ossendorff R, Wang S, Kurth S, Jaenisch M, Assaf E, Strauss AC, Bertheloot D, Welle K, Burger C, Wirtz DC, Schildberg FA.   +10 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Large language model evaluation in autoimmune disease clinical questions comparing ChatGPT 4o, Claude 3.5 Sonnet and Gemini 1.5 pro. [PDF]

Sci Rep
Ma J, Yu J, Xie A, Huang T, Liu W, Ma M, Tao Y, Zang F, Zheng Q, Zhu W, Chen Y, Ning M, Zhu Y.   +12 more
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Breast cancer risk assessment based on a predictive model: evaluation of risk factors among Japanese women. [PDF]

BMC Cancer
Yamada M, Chishima T, Ishikawa T, Narui K, Sugae S, Tonellato PJ, Endo I.   +6 more
europepmc   +1 more source