Results 81 to 90 of about 58,163,280 (350)

An Evaluation of FY10-20 Experience [PDF]

, 2021
Globally, conflict is becoming more complex and intense. The World Bank’s contributions to reducing poverty and boosting shared prosperity increasingly rely on its ability to engage effectively in situations
Independent Evaluation Group
core   +1 more source

New antidepressant mechanism of Yueju Pill: Increasing ghrelin level by inhibiting gastric mTOR/S6K signaling pathway and sensitizing hippocampal GHS-R

Heliyon
Background and aim: Yueju Pill (YJ) not only has good antidepressant effect but also can effectively treat digestive system diseases. However,it remains unclear whether the mechanism of antidepressant action of YJ is related to the peripheral digestive ...
Zhentao Zhang, Dan Su, Meixizi Lai, Yonggui Song, Huizhen Li, Ming Yang, Genhua Zhu, Hong Liu, Zhifu Ai   +8 more
doaj   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

The zebrafish model: a versatile platform for uncovering the therapeutic potential of phytochemicals in liver diseases

Frontiers in Pharmacology
The search for novel therapeutics for prevalent liver diseases such as metabolic dysfunction-associated steatotic liver disease, alcohol-related liver disease, and drug-induced liver injury is constrained by the methodological gaps in conventional ...
Yuliang Liu, Yuliang Liu, Xiang Meng, Xiang Meng, Wei Zhang, Mengmeng Sun, Mengmeng Sun, Ziyoviddin Yusupov, Komiljon Tojibaev, Kobil A. Bobokalonov, Zhenghai Zhang, Min He, Min He, Meiying Jin, Meiying Jin   +14 more
doaj   +1 more source

Model Evaluation: An Adequacy-for-Purpose View

Philosophia Scientiæ, 2020
According to an adequacy-for-purpose view, models should be assessed with respect to their adequacy or fitness for particular purposes. Such a view has been advocated by scientists and philosophers alike.
W. Parker
semanticscholar   +1 more source

Evaluating health risk models [PDF]

Statistics in Medicine, 2010
AbstractInterest in targeted disease prevention has stimulated development of models that assign risks to individuals, using their personal covariates. We need to evaluate these models and quantify the gains achieved by expanding a model to include additional covariates.
openaire   +3 more sources

Evaluation of Markov Models with Discontinuities [PDF]

Medical Decision Making, 2019
Background. Several methods, such as the half-cycle correction and the life-table method, were developed to attenuate the error introduced in Markov models by the discretization of time. Elbasha and Chhatwal have proposed alternative “corrections” based on numerical integration techniques.
Jorge Pérez-Martín, Iñigo Bermejo, Francisco J. Díez   +2 more
openaire   +3 more sources

A Situational Assessment of the Diagnostic Landscape and Organizational Readiness to Implement Next‐Generation Sequencing at Two Childhood Cancer Treatment Centers in Ghana

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Next‐generation sequencing (NGS) has emerged as a promising approach to improve diagnostic accuracy, but its feasibility in low‐ and middle‐income countries remains unknown. This study characterized the diagnostic landscape and assessed organizational readiness for NGS implementation at two childhood cancer treatment centers in Accra ...
Melissa Carvalho, Emmanuella Amoako, Nihad Salifu, Lily Gloria Tagoe, Yaw Bediako, Michelle Hermiston, Catherine Segbefia   +6 more
wiley   +1 more source

Evaluation of natural products bioactivity in cardiovascular diseases utilizing zebrafish models: a comprehensive review

Frontiers in Pharmacology
Cardiovascular diseases (CVDs) are a major global health challenge, significantly impacting public health and healthcare systems. Ethnopharmacological remedies and botanical medicines are widely used for the prevention and treatment of CVDs due to their ...
Yiming Wang, Yiming Wang, Yiming Wang, Xiang Meng, Xiang Meng, Xiang Meng, Xuting Song, Xuting Song, Xuting Song, Lulu Wang, Lulu Wang, Lulu Wang, Xianghe Meng, Xianghe Meng, Xiaoya Du, Ziyoviddin Yusupov, Komiljon Tojibaev, Yunpeng Wang, Min He, Min He, Min He, Mengmeng Sun, Mengmeng Sun, Mengmeng Sun   +23 more
doaj   +1 more source