Results 191 to 200 of about 58,163,280 (350)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Correction: Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

Frontiers in Pharmacology
Dan Su, Qianmin Li, Xin Lai, Yonggui Song, Huizhen Li, Zhifu Ai, Qi Zhang, Wenxiang Shao, Ming Yang, Ming Yang, Genhua Zhu   +10 more
doaj   +1 more source

In Vitro and In Ovo CAM Model Evaluation of Periosteum-Derived Micrografts. [PDF]

J Funct Biomater
Almujaydil R, McCann CJ, Nguyen L, D'Aiuto F.   +3 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Vancomycin Therapeutic Drug Monitoring, Clinical Outcomes and Population Pharmacokinetic Model Evaluation in Neonates. [PDF]

Children (Basel)
Chung E, Tabbara N, Seto W, Shah V.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Educational Technology Society 3(4) 2000 ISSN 1436-4522 56

, 2008
This paper provides a description and some reflections on the ongoing development and use of an evaluation model. This model was designed to support the integration of new learning technologies into courses in higher education. The work was part of the
An Evaluation Model, Gordon Joyes
core  

Expanding access to perinatal trauma care: A dual-model evaluation of perinatal narrative exposure therapy training. [PDF]

Psychol Trauma
Addante S, Miller ML, Meyer DJ, Stevens NR, Padin AC.   +4 more
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Moving beyond projects: a logic model evaluation of an established translational simulation program. [PDF]

Adv Simul (Lond)
Petrosoniak A, Tewari A, Beavers L, Chandran N, Sampson K, Léger C, Khodadoust N, Brydges R.   +7 more
europepmc   +1 more source