Results 161 to 170 of about 8,218,767 (336)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Model Evaluation

, 2001
McAvaney, B., Covey, C., Joussaume, S., Kattsov, V., Kitoh, A., Ogana, W., Pitman, A., Weaver, A., Wood, R., Zhao, Z., contributers, ..   +10 more
openaire   +3 more sources

A 18-yr long (1993–2011) snow and meteorological dataset from a mid-altitude mountain site (Col de Porte, France, 1325 m alt.) for driving and evaluating snowpack models

, 2012
Samuel Morin, Yves Lejeune, Bernard Lesaffre, J.-M. Panel, Daniel Poncet, Pierre‐Marie David, Marcel Sudul   +6 more
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Evaluation of urinary bladder fibrogenesis in a mouse model of long-term ketamine injection

, 2016
Cheng‐Huang Shen, Shou‐Chieh Wang, Shou‐Tsung Wang, Shumei Lin, Jiann‐Der Wu, Chang-Te Lin, Yi‐Wen Liu   +6 more
openalex   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

In Vitro and In Ovo CAM Model Evaluation of Periosteum-Derived Micrografts. [PDF]

J Funct Biomater
Almujaydil R, McCann CJ, Nguyen L, D'Aiuto F.   +3 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Correction: Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway

Frontiers in Pharmacology
Dan Su, Qianmin Li, Xin Lai, Yonggui Song, Huizhen Li, Zhifu Ai, Qi Zhang, Wenxiang Shao, Ming Yang, Ming Yang, Genhua Zhu   +10 more
doaj   +1 more source

AI at the Sella Turcica: Multi-Model Large Language Model Evaluation in Pituitary Adenomas. [PDF]

Brain Spine
Aliyeva A, Nevzati E, Grassia F, Riaz M, Mann S, Nasirov R.   +5 more
europepmc   +1 more source