Results 271 to 280 of about 58,163,280 (350)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

A Novel Dynamic Compression Angle-Stable Interlocking Intramedullary Nail: Description, Validation, and Model Evaluation. [PDF]

Vet Med Int
Dias LGGG, Rocha TASS, Malta CAS, Minto BW, Carrera ALC.   +4 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Comparing traditional natural language processing and large language models for mental health status classification: a multi-model evaluation. [PDF]

Sci Rep
Kallstenius T, Capusan AJ, Andersson G, Williamson A.   +3 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

From an Antimicrobial Agent to a constituent of 3D Printed Heterogenous Scaffolds Stimulating Bone Characteristics: An In-vitro and Animal model evaluation. [PDF]

Regen Ther
Daood SA, Xin Yi MT, Ce Mun NW, Ilyas S, Shien LY, En OJ, Bin Qasim SS, Dai Y, Grewal GK, Liit NM, Sriram G, Pichika MR, Mak KK, Bapat RA, Sheikh Z, Daood U.   +15 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Hierarchical modeling of risk factors with and without prior information-the process of regression model evaluation for an example of respiratory diseases in piglet production from daily practice data. [PDF]

Front Vet Sci
Tug T, Mers F, Schäkel F, Höltig D, Kreienbrock L, Ickstadt K.   +5 more
europepmc   +1 more source

Extracting Pulmonary Embolism Diagnoses From Radiology Impressions Using GPT-4o: Large Language Model Evaluation Study. [PDF]

JMIR Med Inform
Mahyoub M, Dougherty K, Shukla A.
europepmc   +1 more source

Application of unified health large language model evaluation framework to In-Basket message replies: bridging qualitative and quantitative assessments. [PDF]

J Am Med Inform Assoc
Hong C, Chowdhury A, Sorrentino AD, Wang H, Agrawal M, Bedoya A, Bessias S, Economou-Zavlanos NJ, Wong I, Pean C, Li F, Pollak KI, Poon EG, Pencina MJ.   +13 more
europepmc   +1 more source