Results 241 to 250 of about 8,218,767 (336)

A Novel Dynamic Compression Angle-Stable Interlocking Intramedullary Nail: Description, Validation, and Model Evaluation. [PDF]

Vet Med Int
Dias LGGG, Rocha TASS, Malta CAS, Minto BW, Carrera ALC.   +4 more
europepmc   +1 more source

Synthetic Voices, Real Threats: Evaluating Large Text-to-Speech Models in Generating Harmful Audio [PDF]

Guangke Chen, Yuhui Wang, Shouling Ji, Luo, Xiapu, Ting Wang   +4 more
openalex   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

From an Antimicrobial Agent to a constituent of 3D Printed Heterogenous Scaffolds Stimulating Bone Characteristics: An In-vitro and Animal model evaluation. [PDF]

Regen Ther
Daood SA, Xin Yi MT, Ce Mun NW, Ilyas S, Shien LY, En OJ, Bin Qasim SS, Dai Y, Grewal GK, Liit NM, Sriram G, Pichika MR, Mak KK, Bapat RA, Sheikh Z, Daood U.   +15 more
europepmc   +1 more source

P-129 Addressing the gaps: evaluating an innovative 24/7 community nursing model for children at end of life [PDF]

Tracie Lewin-Taylor, Megan Smith, Phoebe Robinson, Kimberley Burke, Jolanta Golan   +4 more
openalex   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A review of model evaluation metrics for machine learning in genetics and genomics. [PDF]

Front Bioinform
Miller C, Portlock T, Nyaga DM, O'Sullivan JM.   +3 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Automated Esophageal Cancer Staging From Free-Text Radiology Reports: Large Language Model Evaluation Study.

JMIR Med Inform
Yao Y, Cen X, Gan L, Jiang J, Wang M, Xu Y, Yuan J.   +6 more
europepmc   +1 more source