Results 141 to 150 of about 3,021,902 (318)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Partial Evaluation in Meta Modeling [PDF]
, 2007 Meta modeling is a well-established technique to describe the structure modeling languages. Method engineering environments utilize the technique to provide a flexible environment for defining and adapting modeling environments. We show that basing meta modeling strictly on first-order logic provides not only clean semantics but also the ability to ...
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
OAIS as a reference model for repositories : an evaluation [PDF]
, 2006 The purpose of this document is to evaluate "whether OAIS is an appropriate reference model for use across the variety of repositories being developed within the JISC community" (Campbell 2005, p. 11).
Allinson, Julie
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Developing a Standardised Model for Internal Control Evaluation
, 2004 This study develops an internal control evaluation (ICE) model - a prototype matrix model -which addresses limitations noted in previous studies. 94 auditors from 5 firms evaluated the internal control structure of a fictitious entity using their current
O'Leary, Conor
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The Ohlson Model of Evaluation of Companies:Tutorial for Use [PDF]
The article analyzes the structuring and applicability of the Ohlson Model (OM). The methodology used considered: (i) exploratory research as to the objectives of the study; (ii) bibliographical research as to the procedures applied; and (iii ...
César Medeiros Cupertino +1 more
core
VibroSim: A hybrid computational/empirical model of vibrothermography nondestructive evaluation
, 2016 Vibrothermography is a nondestructive evaluation technique that finds cracks through vibration-induced heating of contacting crack surfaces. Because there are multiple phenomena involved: vibration, vibration-induced heating, and heat flow, all three ...
Tyler Lesthaeghe +11 more
core +2 more sources
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source