Results 241 to 250 of about 20,676,866 (305)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Potential to perpetuate social biases in health care by Chinese large language models: a model evaluation study. [PDF]

Int J Equity Health
Liu C, Zheng J, Liu Y, Wang X, Zhang Y, Fu Q, Yu W, Yu T, Jiang W, Wang D, Liu C.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Novel Dynamic Compression Angle-Stable Interlocking Intramedullary Nail: Description, Validation, and Model Evaluation. [PDF]

Vet Med Int
Dias LGGG, Rocha TASS, Malta CAS, Minto BW, Carrera ALC.   +4 more
europepmc   +1 more source

Image-Based Dietary Assessment Using the Swedish Plate Model: Evaluation of Deep Learning-Based You Only Look Once (YOLO) Models. [PDF]

JMIR Form Res
Chrintz-Gath G, Daivadanam M, Matta L, McKeever S.   +3 more
europepmc   +1 more source

Comparing traditional natural language processing and large language models for mental health status classification: a multi-model evaluation. [PDF]

Sci Rep
Kallstenius T, Capusan AJ, Andersson G, Williamson A.   +3 more
europepmc   +1 more source

From an Antimicrobial Agent to a constituent of 3D Printed Heterogenous Scaffolds Stimulating Bone Characteristics: An In-vitro and Animal model evaluation. [PDF]

Regen Ther
Daood SA, Xin Yi MT, Ce Mun NW, Ilyas S, Shien LY, En OJ, Bin Qasim SS, Dai Y, Grewal GK, Liit NM, Sriram G, Pichika MR, Mak KK, Bapat RA, Sheikh Z, Daood U.   +15 more
europepmc   +1 more source

Hierarchical modeling of risk factors with and without prior information-the process of regression model evaluation for an example of respiratory diseases in piglet production from daily practice data. [PDF]

Front Vet Sci
Tug T, Mers F, Schäkel F, Höltig D, Kreienbrock L, Ickstadt K.   +5 more
europepmc   +1 more source

A review of model evaluation metrics for machine learning in genetics and genomics. [PDF]

Front Bioinform
Miller C, Portlock T, Nyaga DM, O'Sullivan JM.   +3 more
europepmc   +1 more source

Extracting Pulmonary Embolism Diagnoses From Radiology Impressions Using GPT-4o: Large Language Model Evaluation Study. [PDF]

JMIR Med Inform
Mahyoub M, Dougherty K, Shukla A.
europepmc   +1 more source