Results 131 to 140 of about 3,021,902 (318)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Conceptual model evaluation. Towards more paradigmatic rigor
, 2005 Information Systems (IS) research has so far been primarily concerned with the development of new modeling languages, techniques, and methods. Also, evaluation approaches have been developed in order to assess the appropriateness of a modeling approach ...
Recker, Jan C.
core
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
MathematicsThis paper addresses a problem of optimal error quantification in the framework of robust control theory in the 𝓁1 setup. The upper bounds of biased external disturbance and the gains of coprime factor perturbations in a discrete-time linear time ...
Victor F. Sokolov
doaj +1 more source
An Evaluation Model for CSCW Systems
, 2002 CSCW systems usually involve complex informal communication between several users at different geographical locations. An evaluation model focussing especially on organisational and social aspects is the MOA-E model. This model is used for the evaluation
Grundén, Kerstin,
core
Evaluation of Pastoral Programme in Somaliland [PDF]
, 2007 The Somaliland Pastoral Programme was initiated with the aim of strengthening pastoral organisations, before influencing institutions to be more responsive to pastoralist needs.
Githinji, Joseph
core
Curriculum Evaluation in Greece
, 2009 The role of curriculum in the official educational process is widely recognized by the international scientific community. Beginning in the 19th century, and perhaps even earlier, curriculum research began, not only to be systematized, but to also ...
Krikas, Vangelis, Vangelis Krikas
core +2 more sources