Results 101 to 110 of about 86,749,145 (256)

Elevated Preoperative Systemic Immune-Inflammation Index Independently Predicts 30-Day Mortality After Living Donor Liver Transplantation

Life
Background: Systemic inflammation significantly impacts graft survival and clinical outcomes following living donor liver transplantation (LDLT).
Jaesik Park, Jiyoon Bhan, Do Gyeong Lee, Jemin Ko, Minju Kim, Sang Hyun Hong, Chul Soo Park, Hyun Sik Chung   +7 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Too Little, Too Late – Palliation and End Stage Liver Disease

, 2019
Background: End‐stage liver disease (ESLD) is a leading cause of mortality worldwide. Fewer than 60% of patients with decompensated cirrhosis survive after two years, with patients often experiencing distressing symptoms impairing quality of life.
Johnston, Alexander, Haque, Mazhar M, Woodward, Aidan, Clark, Paul J, Valery, Patricia C, Palmer, Andrew, Chen, Hayley, Mickenbecker, Matthew, O'Sullivan, Timothy, Mortimore, Marianne, Rigby, Nicholas   +10 more
core   +1 more source

Dose adaptation of drugs in patients with liver disease [PDF]

, 2009
A detailed introduction into the topic was obtained by developing a German-language online course named “Dose adjustment in Patients with Liver Disease” for the “Swiss Virtual Campus” in collaboration with PNN AG, a spin-off company of the ETH Zurich.
Schlatter-Häner, Chantal
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Bacterial Infections in Patients with Liver Cirrhosis in an Internal Medicine Department

GE: Portuguese Journal of Gastroenterology, 2018
Background and Aims: Liver cirrhosis (LC) is the end stage of multiple processes that lead to hepatic failure and is the 10th most common cause of death in the Western world.
Cristina Lameirão Gomes, Renata Violante Silva, Paulo Carrola, José Presa   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Alterations of Endothelial Glycocalyx During Orthotopic Liver Transplantation in Patients With End-Stage Liver Disease.

, 2015
BACKGROUND Endothelial glycocalyx participates in the maintenance of vascular integrity, and its perturbations cause capillary leakage, loss of vascular responsiveness, and enhanced adhesion of leukocytes and platelets.
Berlakovich, Gabriela, Schiefer, Judith, Lebherz-Eichinger, Diana, Erdös, Gabor, Krenn, Claus G, Bacher, Andreas, Faybik, Peter   +6 more
core   +1 more source

Predicting utility of a Model for End Stage Liver Disease in alcoholic liver disease

, 2006
AIM: To validate the statistic utility of both the Maddrey Discriminant Function score and the Model for End-Stage Liver Disease as predictors of short term (30 d and 90 d) mortality in patients with alcoholic hepatitis and to assess prognostic factors ...
Deutsch, Melanie, Alexopoulou, Dourakis, Spyridon P., Soultati, Aspasia S., Vasilieva, Larissa, Alexandra, Archimandritis, Athanasios J.   +6 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source