Results 71 to 80 of about 86,749,145 (256)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Alcohol-Related End-Stage Liver Disease and Transplantation: The Debate Continues

, 1994
Liver transplantation has been an acceptable treatment for end-stage liver disease for many years. The greatest number of patients needing transplantation for survival are those suffering from alcohol-related end-stage liver disease. Throughout the years,
Kelso, Lynn A.
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Preoperative Nutritional Support in Children with End-Stage Liver-Disease Accepted for Liver-Transplantation - An Approach to Management

, 1990
Pre‐operative nutritional support was studied in 28 children with end‐stage liver disease awaiting orthotopic liver transplantation. Nasogastric supplemental administration of a standard semi‐elemental enteral nutritional formula was compared with a ...
Strong, R, Wilcox, J., Wilcox, J, Shepherd, R. W., Chin, S. E., Strong, R., Shepherd, RW, Cleghorn, GJ, Ong, TH, Cleghorn, G. J., Chin, SE, Patrick, M, Lynch, S, Patrick, M., Ong, T. H., Lynch, S.   +15 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

End-stage liver disease as the only consequence of a mitochondrial respiratory chain deficiency: no contra-indication for liver transplantation

, 2000
The prerequisite for liver transplantation as a therapeutic option for inherited metabolic diseases should be that the enzyme defect, being responsible for the major clinical (hepatic and/or extra-hepatic) abnormalities, is localised in the liver ...
Jong, K.P. de, van Spronsen, FJ, de Jong, KP, Peeters, P.M., Reijngoud, D.J., Bijleveld, CMA, Smit, GPA, Reijngoud, DJ; id_orcid, Schweizer, JJ, Spronsen, D.J. van, Visser, G., Smit, G.P., Schweizer, J.J., Slooff, M.J.H., Peeters, PMJG, Slooff, MJH, Niezen-Koning, K.E., Ruitenbeek, W., Rake, JP, Visser, G, Bijleveld, C.M., Ruitenbeek, W, Niezen-Koning, KE; id_orcid, Niezen-Koning, KE, Reijngoud, DJ, Rake, J.P.   +25 more
core   +1 more source

The role of mean platelet volume in predicting severity and prognosis of liver cirrhosis in Egyptian patients

The Egyptian Journal of Internal Medicine, 2019
Background and aims Liver cirrhosis is a major public health problem in Egypt due to widespread infection of hepatitis C virus. Mean platelet volume (MPV) is a noninvasive, inexpensive parameter of complete blood count.
Mohamed S Mohamed, Mohamed A.A Bassiony, Ayman F. Elsayed Mohamed   +2 more
doaj   +1 more source