Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Efficient parametric analysis of the chemical master equation through model order reduction. [PDF]
Waldherr S, Haasdonk B.
europepmc +1 more source
Optimal model order reduction with the Steiglitz-McBride method for open-loop data [PDF]
Niklas Everitt +2 more
openalex +1 more source
Model Order Reduction for Linear Time-Invariant System With Symmetric Positive-Definite Matrices: Synthesis of Cauer-Equivalent Circuit [PDF]
Shingo Hiruma, Hajime Igarashi
openalex +1 more source
Data-driven parameterized model order reduction using z-domain multivariate orthonormal vector fitting technique [PDF]
A.E. Ruehli +18 more
core +2 more sources
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Optimal Sparse Energy Sampling for X-ray Spectro-Microscopy: Reducing the X-ray Dose and Experiment Time Using Model Order Reduction. [PDF]
Quinn PD +5 more
europepmc +1 more source
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source

