Results 211 to 220 of about 7,286,935 (343)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Model reduction for fatigue life estimation of a welded joint driven by machine learning. [PDF]

Heliyon
Amuzuga P, Bennebach M, Iwaniack JL.
europepmc   +1 more source

Fuzzification-back propagation neural network-based model prediction for robotic arm positioning error reduction

Jiang Liu, Jian Wu, Jiansheng Pan, Pengyue Zhao   +3 more
openalex   +1 more source

Reduction of Maximum Entropy Models to Hidden Markov Models [PDF]

, 2012
Joshua Goodman
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

How synaptic function controls critical transitions in spiking neuron networks: insight from a Kuramoto model reduction. [PDF]

Front Netw Physiol
Smirnov LA, Munyayev VO, Bolotov MI, Osipov GV, Belykh I.   +4 more
europepmc   +1 more source

APPLYING PARAMETRIC MODELING TO DEVELOP AN ENERGY EFFICIENT DESIGN OF THE ALUMINUM REDUCTION CELL ANODE ASSEMBLY

, 2017
Anton Viktorovich Zavizin, Tatiana V. Piskazhova, Aleksei V. Lineitsev, Yaroslav A. Tretiakov   +3 more
openalex   +1 more source

Interpolatory model reduction [PDF]

Systems & Control Letters, 2013
Garret Flagg, Christopher A. Beattie, Serkan Gugercin   +2 more
openaire   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Analysis of a detailed multi-stage model of stochastic gene expression using queueing theory and model reduction. [PDF]

Math Biosci
Ma M, Szavits-Nossan J, Singh A, Grima R.   +3 more
europepmc   +1 more source