Results 121 to 130 of about 1,328,506 (341)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Model reference adaptive integral sliding mode control for switched delay systems [PDF]

, 2008
Makalenin ilk sayfası kayda eklenmiştir.This paper proposes a strategy of model reference adaptive integral sliding mode variable structure control to solve the tracking problem for a class of uncertain switched systems with time-varying delay.
Dimirovski, Georgi M., Lian, Jie, Zhao, Jun   +2 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Study on Model Reference Adaptive Control for Subway Pantographs

Kongzhi Yu Xinxi Jishu
The coupling performance of subway pantographs with catenaries affects the quality of current collection and the safety of trains. The rigidity of these catenaries exhibits periodicity and fluctuations due to factors such as geographical locations ...
YANG Gang, SHEN Xin, KONG Guowei
doaj  

Constrained Nonlinear Model Predictive Control of an MMA Polymerization Process via Evolutionary Optimization

, 2014
In this work, a nonlinear model predictive controller is developed for a batch polymerization process. The physical model of the process is parameterized along a desired trajectory resulting in a trajectory linearized piecewise model (a multiple linear ...
Abbaszadeh, Masoud, Solgi, Reza
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Transition Process Control of Tiltrotor Aircraft Based on Fractional-Order Model Reference Adaptive Control

Machines
To address the critical challenge of controlling tiltrotor aircraft during transition mode, this paper proposes a fractional-order model reference adaptive control (FO-MRAC) method based on the unique modeling of the tiltrotor aircraft. A nonlinear model
Junkai Liang, Hui Ye, Yaohua Shen, Dawei Wu   +3 more
doaj   +1 more source

Digital adaptive controllers for VTOL vehicles. Volume 1: Concept evaluation [PDF]

A digital self-adaptive flight control system was developed for flight test in the VTOL approach and landing technology (VALT) research aircraft (a modified CH-47 helicopter).
Hartmann, G. L., Pratt, S. G., Stein, G.
core   +1 more source

A Heuristic Approach for Discovering Reference Models by Mining Process Model Variants [PDF]

, 2009
Recently, a new generation of adaptive Process-Aware Information Systems (PAISs) has emerged, which enables structural process changes during runtime while preserving PAIS robustness and consistency.
Li, C., Reichert, M.U., Wombacher, A.
core   +5 more sources