Results 261 to 270 of about 7,849,545 (341)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Gaussian kernelized transformer learning model for brain tumor risk factor identification and disease diagnosis

P. S. Renjeni, B. Senthilkumaran, R. Sugumar, Jaya Singh Dhas   +3 more
openalex   +2 more sources

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Modeling Mortality Risk Among HIV/AIDS Patients on Antiretroviral Therapy Using Survival Methods: Insights from Kaplan-Meier, Cox Proportional Hazards Models, and Log Rank Tests

Winfred Karimi, Robert Muriungi Gitunga, Frank Onyambu, Christine Gacheri   +3 more
openalex   +2 more sources

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Forecasting Waitlist Trajectories for Patients With Metabolic Dysfunction-Associated Steatohepatitis Cirrhosis: A Neural Network Competing Risk Analysis.

J Med Internet Res
Punchhi G, Sun Y, Tan E, Hlaing NKT, Liu C, Asrani S, Rambhatla S, Bhat M.   +7 more
europepmc   +1 more source

Early warning of Enterprise financial risk based on stochastic forest model

Xianmei Xia
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

DISTENDER indicators for Round 1 (only climate signal) and for: Air Quality and Emissions; Urban Heat Island; Health; Water; Energy; Agroforestry; Sectorial economy; Risk and Vulnerability. Case study: Dehesas (Spain) and Montados (Portugal) (EURAF). Global climate model: EC-EARTH3. Scenario: SSP370.

DISTENDER, ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON UOA, UNIVERSIDADE DE AVEIRO, UNIVERSITAT ZU KOLN, CLIMATE SOLUTIONS UNIPESSOAL LDA, UNIVERSIDAD POLITECNICA DE MADRID, UK CENTRE FOR ECOLOGY & HYDROLOGY   +6 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source