Results 121 to 130 of about 6,409,464 (276)

Topological model selection: a case-study in tumour-induced angiogenesis. [PDF]

Bioinformatics
McDonald RA, Byrne HM, Harrington HA, Thorne T, Stolz BJ.   +4 more
europepmc   +1 more source

Balancing Revenue Streams in Online Video Platforms: The Impact of Original Content Provision on Business Model Selection

Zhuoning Zhang, Zhongsheng Hua
openalex   +2 more sources

Selective inference after likelihood- or test-based model selection in linear models [PDF]

, 2017
David Rügamer, Sonja Greven
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Correction: Minimum uncertainty as Bayesian network model selection principle. [PDF]

BMC Bioinformatics
Gogoshin G, Rodin AS.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Pharmacokinetic Model Selection for Personalized Infliximab Dosing in IBD. [PDF]

CPT Pharmacometrics Syst Pharmacol
Chaiben S, Gandia P, Jamme T, Congy N, Concordet D.   +4 more
europepmc   +1 more source

Efficient model selection in switching linear dynamic systems by graph clustering [PDF]

, 2020
Parisa Karimi, Mark D. Butala, Zhizhen Zhao, Farzad Kamalabadi   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

SplitWise regression for capturing nonlinear effects in interpretable model selection. [PDF]

Sci Rep
Kurbucz MT, Tzivanakis N, Sari Aslam N, Sykulski AM.   +3 more
europepmc   +1 more source