Results 161 to 170 of about 346,476 (312)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Detecting strongly connected components in large distributed state spaces [PDF]
, 2005 Detecting cycles in a state space is a key task in verification algortihms like LTL/CTL model checking and, less well known, reduction modulo branching bisimulation.
Pol, van de, J.C. +3 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Scott models are topological models of complete partial orders used for Tarskian fixed point semantics of the lambda calculus. As of yet there are no methods for deriving Scott models from specifications of the "complete" objects beyond an arbitrary ...
Matthews, Stephen G.
core
Models for torsion spaces [PDF]
, 1998 Given an integer n > 1 and any set P of positive integers, one can assign to each topological space X a homotopy universal map X (P,n) → X where X (P,n) is an (n-1)-connected CW-complex whose homotopy groups are P-torsion. We analyze this construction
Paricio, L.J.H. [0000-0003-4528-7781] +2 more
core
Modeling the Cost of Green Space Investment in Residential Areas in Dar es Salaam City, Tanzania
Journal of Applied Sciences and Environmental ManagementUnderstanding the costs of development, maintenance and replacement of green spaces may help in effective planning and development of green spaces. However, traditional methods to ascertain the costs of the same are complex and requires many data and ...
N. F. Mwageni
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source