Results 91 to 100 of about 5,427,905 (301)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
IEEE Access, 2019 With the rapid growth of installed capacity of photovoltaic (PV), the PV power stations equipped with energy storage (ES) have become a new type of black-start power supply.
Junhui Li +5 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Labor market prospects search intensity and the transition from college to work [PDF]
In this paper we develop a structural model for job search behavior of students entering the labor market. The model includes endogenous search effort and on the job search.
Berkhout, Peter +2 more
core
Thermal phase transitions in cosmology [PDF]
, 2001 We review briefly the current status of thermal phase transitions within the Standard Model and its simplest extensions. We start with an update on QCD thermodynamics, then discuss the electroweak phase transition, particularly in supersymmetric ...
Laine, M.
core +1 more source
, 2017 Traditional recommendation systems rely on past usage data in order to generate new recommendations. Those approaches fail to generate sensible recommendations for new users and items into the system due to missing information about their past ...
A Rajaraman +4 more
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
INFRASTRUCTURE ASPECTS OF INNOVATION ACTIVITY OF THE RUSSIAN FEDERATION NORTH-WEST REGION
Дискурс, 2016 The article describes the main elements of the innovation infrastructure. The method of selecting a business model for the formation and development of educational areas infrastructure based on the analytic hierarchy process is proposed.
M. A. Kosuhina
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source