Results 51 to 60 of about 11,862,226 (291)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Calculation Method for Torsional Angle of Main Cables of Suspension Bridges with Spatial Cables

Applied Sciences
In suspension bridges employing spatial cables, the main cables undergo torsion during the construction process. Clarifying the distribution pattern of the main cable torsional angle can guide the positioning and installation of cable clamps and mitigate
Shengbo Chai, Qingyu Zhao, Cailin Zheng, Shang Chen   +3 more
doaj   +1 more source

Model Tests and Interpretation of Earth Pressure Behind Existing and Newly Added Double-Row Piles Retaining Underground Supplementary Excavation

Buildings
In urban redevelopment, adding basements beneath existing buildings often requires specialized retaining structures, such as existing and newly added double-row piles, yet their complex load-sharing mechanism is not yet fully understood.
Yiming Jin, Feng Yu, Jiahui Ye, Zijun Wang   +3 more
doaj   +1 more source

Loglinear Rasch Model Tests [PDF]

Psychometrika, 1984
Existing statistical tests for the fit of the Rasch model have been criticized, because they are only sensitive to specific violations of its assumptions. Contingency table methods using loglinear models have been used to test various psychometric models.
openaire   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Experimental Study on Bearing Characteristics of Pile-Anchor Foundations for Floating Offshore Wind Turbines Under Inclined Loading

Journal of Marine Science and Engineering
Pile-anchor foundations, serving as one of the anchoring solutions to ensure the safety and stability of floating offshore wind turbines, are primarily subjected to inclined loading induced by anchor chain forces, resulting in significantly different ...
Yuxuan Wang, Pingyu Liu, Bo Liu, Jiaqing Shu, Huiyuan Deng, Mingxing Zhu, Xiaojuan Li, Jie Chen, Haoran Ouyang   +8 more
doaj   +1 more source

Model Tests on Characteristic of Suction Caissons in Saturated Fine Sand Under Intermittent Loading

Polish Maritime Research, 2018
Suction caissons are often used for the caissons of both offshore oil platforms and offshore wind power projects because of their advantages of simple construction, economical cost, and reusability.
Shi Ping
doaj   +1 more source

Numerical simulation of masonry building deformation and failure characteristics in landslide tension areas

地质科技通报, 2023
To ensure the safety of life and property of residents on landslides and reveal the deformation and failure law of masonry buildings on landslides, it is necessary to carry out a simulation study on the deformation and failure process of masonry ...
Youming Han, Lei Du, Xinghua Zhu, Lixia Chen, Yuting Yu, Qin Chen   +5 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Impacts of navigable flow conditions at the confluence of main and tributary streams of a cross-basin canal with high drop geomorphology—a case study of the confluence section of Qinjiang River in Pinglu Canal

Frontiers in Water
The Pinglu Canal is a cross-basin canal project. The Qinjiang River, serving as a vital tributary of the Pinglu Canal, exhibits a significant elevation differential between its riverbed and the canal bed.
Linfeng Han, Ling Cheng, Tao Yu, Shengfa Yang, Junhui He   +4 more
doaj   +1 more source