Results 131 to 140 of about 1,058,068 (314)
UML Sequence Diagram: Transformation from the Two-Hemisphere Model and Layout
Applied Computer Systems, 2013 Modeling of the object interaction is one of the core tasks during system analysis and design, because it gives developer an ability to define responsibilities of class objects and to sketch general architecture of software components.
Nikiforova Oksana +2 more
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FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Towards an effective approach for composition of model transformations
Frontiers in Computer ScienceModel Driven Engineering (MDE) adoption in the industry suffers from many technical and non-technical problems. One of the significant technical problems lies in the difficulty of building complex transformations from the composition of small and ...
Hamza Abdelmalek +2 more
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The Knowledge Frame System based on Principles of Topological Functioning Model
Applied Computer Systems, 2017 Understanding of domain phenomena and their interrelations is necessary for successful software development. The knowledge frame system based on principles of Topological Functioning Modelling (TFM) can be used for this purpose at the Computation ...
Nazaruks Vladislavs
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Pairwise Comparison Estimation of Censored Transformation Models [PDF]
In this paper a pairwise comparison estimation procedure is proposed for the regression coefficients in a censored transformation model. The main advantage of the new estimator is that it can accommodate covariate dependent censoring without the ...
Elie Tamer, Shakeeb Khan
core
Estimation of a Transformation Model with Truncation, Interval Observation and Time–Varying Covariates [PDF]
Abrevaya (1999b) considered estimation of a transformation model in the presence of left–truncation. This paper observes that a cross–sectional version of the statistical model considered in Frederiksen, Honoré, and Hu (2007) is a generalization of the ...
Bo E. Honoré, Luojia Hu
core +3 more sources
IEEE AccessIndustrial model-driven engineering often struggles to generate functionally complete code, especially dynamic behaviors, from large-scale Meta-models, typically yielding only static structures.
Tong Ma +4 more
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source