Results 51 to 60 of about 752,870 (293)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Field-Test-Driven Sensitivity Analysis and Model Updating of Aging Railroad Bridge Structures Using Genetic Algorithm Optimization Approach

Infrastructures
Aging railroad bridges present complex challenges due to advancing deterioration and outdated design assumptions. This study develops a comprehensive analytical approach for assessing an aging steel truss railroad bridge through finite element (FE ...
Rahul Anand, Sachin Tripathi, Celso Cruz De Oliveira, Ramesh B. Malla   +3 more
doaj   +1 more source

Model predictive control of a crude oil distillation column [PDF]

Modeling, Identification and Control, 1999
The project of designing and implementing model based predictive control on the vacuum distillation column at the Nynäshamn Refinery of Nynäs AB is described in this paper.
Morten Hovd, Rune Michaelsen, Tomas Montin   +2 more
doaj   +1 more source

Update on desiccant wheel model

International Journal of Energy Research, 2004
This short communication presents the update on the desiccant wheel models, developed earlier by the present authors. It is to be mentioned here that the psycrometric model presented earlier (Int. J. Energy Res., 2003; 27:17) is valid only for the desiccant wheel running with identical volume air-flows in supply and regeneration sides.
FRANZITTA, Vincenzo, BECCALI, Marco, BUTERA, Fabio, ADHIKARI R. S.   +3 more
openaire   +4 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Structural Damage Detection Using Adversarially Calibrated Simulations and Deep Learning from Frequency-Domain Signals

Applied Sciences
Structural Damage Detection is an area that is becoming increasingly important as structure age and become more prone to failure. Early identification of these changes can lead to significant cost savings and potential damage reduction. Conventional data-
César Peláez-Rodriguez, Álvaro Iglesias-Pordomingo, Sancho Salcedo-Sanz, Antolin Lorenzana, Alvaro Magdaleno   +4 more
doaj   +1 more source

Experimental Tests and Numerical Analyses for the Dynamic Characterization of a Steel and Wooden Cable-Stayed Footbridge

Infrastructures, 2023
Vibrations are an issue of increasing importance in current footbridge design practice. More sophisticated footbridges with increasing spans and more effective construction materials result in lightweight structures and a high ratio of live load to dead ...
Vanni Nicoletti, Simone Quarchioni, Luca Tentella, Riccardo Martini, Fabrizio Gara   +4 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Finite Element Model Updating Using Resonance–Antiresonant Frequencies with Radial Basis Function Neural Network

Applied Sciences, 2023
The modal frequencies, model shapes or their derivatives are generally used as the characteristic quantities of the objective function for the finite element model (FEM) updating.
Haifeng Zhao, Jianzhuo Lv, Zunce Wang, Tianchi Gao, Wenhao Xiong   +4 more
doaj   +1 more source